Gram negative bacteria carbapenemase isolated from hospitalized patients of IESS Hospital Portoviejo, Ecuador

Abstract

Enterobacterias present a natural resistance profile makes them capable of hydrolyzing beta-lactam antibiotics through the production of of enzymes called beta-lactamases and also their genetic material is capable of mutating and acquiring mechanisms of multiple resistances, it are the main microorganisms involved in the origin of infectious diseases in humans, such as bacteremia, peritonitis, nosocomial pneumonia, urinary tract infections and meningitis. In the study carried out in the IESS General Hospital of the city Portoviejo, analyzed the prevalence of Gram-negative bacteria producing carbapenemases isolated from hospitalized patients,  the most frequent gender was male with 70% and the mean age was over 61 years, whose situation is of consideration, as these patients are more susceptible and more difficult to treat. Out of 1,139 isolations in different areas, most of which corresponded to male patients (63%). There was a 4% prevalence of Gram-negative bacteria with mechanisms of resistance to carbapenemics, where the most frequently isolated were Klebsiella pneumoniae and Acinetobacter baumannii; while the phenotypic distribution was 100% of KPC-type carbapenemases (Klebsiella pneumoniae carbapenemases).The prevalence of Gram-negative bacteria corresponded to 60% carbapenemase-producing Klebsiella pneumoniae.