Coinfección entre SARS-COV-2 y dengue en pacientes de Jipijapa de marzo a diciembre del 2020
Autores
- Cinthya Verónica Acosta Santana Programa de Maestría en Biomedicina, Instituto de Posgrado, Universidad Técnica de Manabí. Hospital del Día Jipijapa, Instituto Ecuatoriano de Seguridad Social, Jipijapa, Manabí, Ecuador
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Minerva Casilda Donate Pino
Universidad Técnica de Manabí, Facultad de Ciencias de la Salud, Carrera de Medicina, Portoviejo, Manabí, Ecuador
https://orcid.org/0000-0002-5139-4885
DOI:
https://doi.org/10.33936/qkrcs.v7i1.5533Palavras-chave:
SARS-COV-2, COVID-19, dengue, coinfección, biomarcadoresResumo
El dengue es la enfermedad arboviral más común en las regiones tropicales y subtropicales del mundo. Al igual que otras regiones, las áreas endémicas de dengue han enfrentado el impacto socioeconómico y de salud pública adicional de la pandemia de la enfermedad por coronavirus 2019 (COVID-19). Las coinfecciones por SARS-CoV-2 y el virus del dengue (DENV) han sido informadas con manejo complicado del paciente y requisitos de atención. El presente estudio tuvo como objetivo, evaluar la coinfección por SARS-CoV-2 y DENV, confirmados a través de técnicas moleculares e inmunológicas, en pacientes atendidos entre marzo y diciembre del 2020, en el Hospital del Día Jipijapa del Instituto Ecuatoriano de Seguridad Social. Se realizó un estudio de tipo transversal, observacional y retrospectivo. La población estuvo constituida por 239 pacientes de entre 10 y 90 años de edad. El muestreo fue no probabilístico. El diagnóstico de COVID-19 se confirmó mediante el ensayo de reacción en cadena de la polimerasa con transcripción inversa (qRT-PCR) de muestras de hisopado nasofaríngeo, mientras que el diagnóstico de dengue se determinó mediante una prueba rápida para NS1Ag/IgG/IgM. El 3,35 % de los pacientes con sintomatología, presentó coinfección, afectando en mayor proporción al sexo masculino. Los principales síntomas se asociaron con malestar general, fiebre, cefalea, dolor abdominal, deposiciones líquidas y tos no productiva. Los resultados de los marcadores hematológicos indicaron leucopenia, leucocitosis y trombocitopenia.
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Referências
1. Bicudo N, Bicudo E, Costa JD, Castro JALP, Barra GB. Co-infection of SARSCoV-2 and dengue virus: a clinical challenge. Braz J Infect Dis [Internet]. 2020;24(5):452-4. Disponible en: https://doi.org/10.1016/j.bjid.2020.07.008
2. Harapan H, Ryan M, Yohan B, Abidin RS, Nainu F, Rakib A, Jahan I, Emran TB, Ullah I, Panta K, Dhama K, Sasmono RT. Covid-19 and dengue: Double punches for dengue-endemic countries in Asia. Rev Med Virol [Internet]. 2021;31(2):e2161. Disponible en: https://doi.org/10.1002/rmv.2161
3. Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. JAMA [Internet]. 2020;324(8):782-793. Disponible en: https://doi.org/10.1001/jama.2020.12839
4. Pascarella G, Strumia A, Piliego C, Bruno F, Del Buono R, Costa F, Scarlata S, Agrò FE. COVID-19 diagnosis and management: a comprehensive review. J Intern Med [Internet]. 2020;288(2):192-206. Disponible en: https://doi.org/10.1111/joim.13091
5. Gómez AMA, Favorito LA. The Social, Economic and Sanitary Impact of COVID-19 Pandemic. Int braz j urol [Internet]. Int Braz J Urol [Internet]. 2020;46(Suppl 1):3-5. Disponible en: https://doi.org/10.1590/S1677-5538.IBJU.2020.S1ED2
6. de Oliveira Andrade R. Covid-19 is causing the collapse of Brazil's national health service. BMJ [Internet]. 2020;370:m3032. Disponible en: https://doi.org/10.1136/bmj.m3032
7. Lima LD, Pereira AMM, Machado CV. Crisis, conditioning factors, and challenges in the coordination of Brazil's federative State in the context of COVID-19. Cad Saude Publica [Internet]. 2020;36(7):e00185220. Disponible en: https://doi.org/10.1590/0102-311x00185220
8. Saavedra-Velasco M, Chiara-Chilet C, Pichardo-Rodriguez R, Grandez-Urbina A, Inga-Berrospi F. Coinfección entre dengue y COVID-19: Necesidad de abordaje en zonas endémicas. Rev Fac Cien Med Univ Nac Cordoba [Internet]. 2020;77(1):52-4. Disponible en: https://doi.org/10.31053/1853.0605.v77.n1.280
9. de Souza CDF, do Carmo RF, Machado MF. The burden of COVID-19 in Brazil is greater in areas with high social deprivation. J Travel Med [Internet]. 2020;27(7):taaa145. Disponible en: https://doi.org/10.1093/jtm/taaa145
10. Martins-Filho PR, de Souza Araújo AA, Quintans-Júnior LJ, Santos VS. COVID-19 fatality rates related to social inequality in Northeast Brazil: a neighbourhood-level analysis. J Travel Med [Internet]. 2020;27(7):taaa128. Disponible en: https://doi.org/10.1093/jtm/taaa128.
11. Butt MH, Ahmad A, Misbah S, Mallhi TH, Khan YH. Dengue fever and COVID-19 coinfection; a threat to public health for coepidemic in Pakistan. J Med Virol [Internet]. 2021;93(2):671-672. Disponible en: https://doi.org/10.1002/jmv.26464
12. Estofolete CF, Machado LF, Zini N, Luckemeyer GD, Moraes MM, Dos Santos TMIL, Dos Santos BF, Ruiz LGP, Vasilakis N, Lobo SMA, Nogueira ML. Presentation of fatal stroke due to SARS-CoV-2 and dengue virus coinfection. J Med Virol [Internet]. 2021;93(3):1770-5. Disponible en: https://doi.org/10.1002/jmv.26476
13. Lazzarini L, Barzon L, Foglia F, Manfrin V, Pacenti M, Pavan F, Rassu M, Capelli G, Montarsi F, Martini S, Zanella F, Padovan MT, Russo F, Gobbi F. First autochthonous dengue outbreak in Italy, August 2020. Euro Surveill [Internet]. 202;25:8-11. Disponible en: https://doi.org/10.2807/1560-7917.ES.2020.25.36.2001606
14. Contreras M, Rincón MA, Vásquez A, Moreira R, Callejas D. Aspectos genéticos del virus del dengue. QhaliKay Revista de Ciencias de la Salud [Internet]. 2021;5(2):79-88. Disponible en: https://revistas.utm.edu.ec/index.php/QhaliKay/article/view/3496/3354
15. Olive MM, Baldet T, Devillers J, Fite J, Paty MC, Paupy C, Quénel P, Quillery E, Raude J, Stahl JP, Thiann-Bo-Morel M, Roiz D. The COVID-19 pandemic should not jeopardize dengue control. PLoS Negl Trop Dis [Internet]. 2020;14(9):e0008716. Disponible en: https://doi.org/10.1371/journal.pntd.0008716
16. Wu D, Lu J, Liu Q, Ma X, He W, 2020a. To alert co-infection of SARS-COV-2 and dengue virus in developing countries in the dengue-endemic area. Infect Control Hosp Epidemiol [Internet]. 2020:1. Disponible en: https://doi.org/10.1017/ice.2020.187
17. Saddique A, Rana MS, Alam MM, Ikram A, Usman M, Salman M, Faryal R, Massab U, Bokhari H, Mian MS, Israr A, Safiullah. Emergence of co-infection of COVID-19 and dengue: A serious public health threat. J Infect [Internet]. 2020;81(6):e16-e18. Disponible en: https://doi.org/10.1016/j.jinf.2020.08.009
18. Wilder-Smith A. Dengue vaccine development by the year 2020: challenges and prospects. Curr Opin Virol [Internet]. 2020;43:71-78. Disponible en: https://doi.org/10.1016/j.coviro.2020.09.004
19. Prapty CNBS, Rahmat R, Araf Y, Shounak SK, Noor-A-Afrin, Rahaman TI, Hosen MJ, Zheng C, Hossain MG. SARS-CoV-2 and dengue virus co-infection: Epidemiology, pathogenesis, diagnosis, treatment, and management. Rev Med Virol [Internet]. 2023;33(1):e2340. Disponible en: https://doi.org/10.1002/rmv.2340
20. Hou H, Zhang B, Huang H, Luo Y, Wu S, Tang G, Liu W, Mao L, Mao L, Wang F, Sun Z. Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19. Clin Exp Immunol [Internet]. 2020;201(1):76-84. Disponible en: https://doi.org/10.1111/cei.13450.
21. Flores-Mendoza LK, Estrada-Jiménez T, Sedeño-Monge V, Moreno M, Manjarrez MDC, González-Ochoa G, Millán-Pérez Peña L, Reyes-Leyva J. IL-10 and socs3 Are Predictive Biomarkers of Dengue Hemorrhagic Fever. Mediators Inflamm [Internet]. 2017;2017:5197592. Disponible en: https://doi.org/10.1155/2017/5197592
22. John DV, Lin YS, Perng GC. Biomarkers of severe dengue disease - a review. J Biomed Sci [Internet]. 2015;22:83. Disponible en: https://doi.org/10.1186/s12929-015-0191-6
23. Cardona-Ospina JA, Arteaga-Livias K, Villamil-Gómez WE, Pérez-Díaz CE, Katterine Bonilla-Aldana D, Mondragon-Cardona Á, Solarte-Portilla M, Martinez E, Millan-Oñate J, López-Medina E, López P, Navarro JC, Perez-Garcia L, Mogollon-Rodriguez E, Rodríguez-Morales AJ, Paniz-Mondolfi A. Dengue and COVID-19, overlapping epidemics? An analysis from Colombia. J Med Virol [Internet]. 2021;93(1):522-527. Disponible en: https://doi.org/10.1002/jmv.26194
24. Seputra DPGS, Saraswati KSD, Dewi AAISK. Co‐infection of COVID‐19 and dengue: a case report. Int J Adv Med [Internet]. 2021;8:4. Disponible en: https://doi.org/10.18203/2349‐3933.ijam20212869
25. Radisic MV, Piro MA, Mori I, Rotryng F, Santamarina JF. Sars-cov-2 and dengue virus co-infection. A case report. Infezioni in Medicina [Internet]. 2020;28(3):416-9. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32920578/
26. Pontes RL, de Brito BB, da Silva FAF, Figueredo MS, Correia TML, Teixeira AF, et al. Coinfection by SARS-CoV-2 and dengue virus in a dual viral circulation setting. Travel Med Infect Dis [Internet]. 2020;37:101862. Disponible en: https://doi.org/10.1016/j.tmaid.2020.101862
27. Verduyn M, Allou N, Gazaille V, Andre M, Desroche T, Jaffar MC, et al. Coinfection of dengue and covid-19: a case report. PLoS Negl Trop Dis [Internet]. 2020;14(8):1-5. Disponible en: https://doi.org/10.1371/journal.pntd.0008476
28. Epelboin L, Blondé R, Nacher M, Combe P, Collet L. COVID-19 and dengue co-infection in a returning traveller. J Travel Med [Internet]. 2020;27(6).taaa114. Disponible en: https://doi.org/10.1093/jtm/taaa114
29. Mahajan NN, Kesarwani SN, Shinde SS, Nayak A, Modi DN, Mahale SD, et al. Coinfection of malaria and dengue in pregnant women with SARS-CoV-2. Int J Gynaecol Obstet [Internet]. 2020;151(3):459-62. Disponible en: https://doi.org/10.1002/ijgo.13415
30. Kembuan GJ. Dengue serology in Indonesian COVID-19 patients: coinfection or serological overlap? IDCases [Internet]. 2020;22:e00927. Disponible en: https://doi.org/10.1016/j. idcr.2020.e00927
31. Somasetia DH, Malahayati TT, Andriyani FM, Setiabudi D, Nataprawira HM. A fatal course of multiple inflammatory syndrome in children coinfection with dengue. A case report from Indonesia. IDCases [Internet]. 2020;22:e01002. Disponible en: https://doi.org/10.1016/j.idcr.2020.e01002
32. Masyeni S, Santoso MS, Widyaningsih PD, Asmara DW, Nainu F, Harapan H, Sasmono RT. Serological cross-reaction and coinfection of dengue and COVID-19 in Asia: Experience from Indonesia. Int J Infect Dis [Internet]. 2021;102:152-154. Disponible en: https://doi.org/10.1016/j.ijid.2020.10.043
33. Lokida D, Lukman N, Salim G, Butar-Butar DP, Kosasih H, Wulan WN, et al. Diagnosis of COVID-19 in a dengue-endemic area. Am J Trop Med Hyg [Internet]. 2020;103(3):1220-2. Disponible en: https://doi.org/10.4269/ajtmh.20-0676
34. Ratnarathon AC, Pongpirul K, Pongpirul WA, Charoenpong L, Prasithsirikul W. Potential dual dengue and SARS-CoV-2 infection in Thailand: A case study. Heliyon [Internet]. 2020;6(6). Disponible en: https://doi.org/10.1016/j.heliyon.2020.e04175
35. Teotônio IMSN, de Carvalho JL, Castro LC, Nitz N, Hagström L, Rios GG, de Fátima Rodrigues de Oliveira M, Dallago BSL, Hecht M. Clinical and biochemical parameters of COVID-19 patients with prior or active dengue fever. Acta Trop [Internet]. 2021;214:105782. Disponible en: https://doi.org/10.1016/j.actatropica.2020.105782
36. Nicolelis MAL, Raimundo RLG, Peixoto PS, Andreazzi CS. How Super-Spreader Cities, Highways, Hospital Bed Availability, and Dengue Fever Influenced the Covid-19 Epidemic in Brazil. MedRxiv [Internet]. 2020;2020:1-50. Disponible en: https://doi.org/10.1101/2020.09.19.20197749
37. Tsheten T, Clements ACA, Gray DJ, Adhikary RK, Wangdi K. Clinical features and outcomes of COVID-19 and dengue co-infection: a systematic review. BMC Infect Dis [Internet]. 2021;21(1):729. Disponible en: https://doi.org/10.1186/s12879-021-06409-9
38. Miah MA, Husna A. Coinfection, coepidemics of COVID-19, and dengue in dengue-endemic countries: A serious health concern. J Med Virol [Internet]. 2021;93(1):161-2. Disponible en: https://doi.org/10.1002/jmv.26269
39. Rosso F, Parra-Lara LG, Agudelo-Rojas OL, Martinez-Ruiz DM. Differentiating Dengue from COVID-19: Comparison of Cases in Colombia. Am J Trop Med Hyg [Internet]. 2021;105(3):745-50. Disponible en: https://doi.org/10.4269/ajtmh.20-0912
40. Ananda Rao A, U RR, Gosavi S, Menon S. Dengue Fever: Prognostic Insights From a Complete Blood Count. Cureus [Internet]. 2020;12(11):e11594. Disponible en: https://doi.org/10.7759/cureus.11594
41. Yang AP, Liu JP, Tao WQ, Li HM. The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. Int Immunopharmacol [Internet]. 2020;84:106504. Disponible en: https://doi.org/10.1016/j.intimp.2020
42. Cui SN, Tan HY, Fan GC. Immunopathological Roles of Neutrophils in Virus Infection and COVID-19. Shock [Internet]. 2021;56(3):345-51. Disponible en: https://doi.org/10.1097/SHK.0000000000001740
43. Vafadar Moradi E, Teimouri A, Rezaee R, Morovatdar N, Foroughian M, Layegh P, Rezvani Kakhki B, Ahmadi Koupaei SR, Ghorani V. Increased age, neutrophil-to-lymphocyte ratio (NLR) and white blood cells count are associated with higher COVID-19 mortality. Am J Emerg Med [Internet]. 2021;40:11-4. Disponible en: https://doi.org/10.1016/j.ajem.2020.12.003
44. Liu Y, Du X, Chen J, Jin Y, Peng L, Wang HHX, Luo M, Chen L, Zhao Y. Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19. J Infect [Internet]. 2020;81(1):e6-e12. Disponible en: https://doi.org/10.1016/j.jinf.2020.04.002
45. Qu R, Ling Y, Zhang YH, Wei LY, Chen X, Li XM, Liu XY, Liu HM, Guo Z, Ren H, Wang Q. Platelet-to-lymphocyte ratio is associated with prognosis in patients with coronavirus disease-19. J Med Virol [Internet]. 2020;92(9):1533-1541. Disponible en: https://doi.org/10.1002/jmv.25767
46. Kantri A, Ziati J, Khalis M, Haoudar A, El Aidaoui K, Daoudi Y, Chikhaoui I, El Yamani K, Mouhaoui M, El Bakkouri J, Dini N, Mahi M, Naitlho A, Bahlaoui A, Bennana A, Noussair M, Belyamani L, El Kettani C. Hematological and biochemical abnormalities associated with severe forms of COVID-19: A retrospective single-center study from Morocco. PLoS One [Internet]. 2021;16(2):e0246295. Disponible en: https://doi.org/10.1371/journal.pone.0246295
47. Fois AG, Paliogiannis P, Scano V, Cau S, Babudieri S, Perra R, Ruzzittu G, Zinellu E, Pirina P, Carru C, Arru LB, Fancellu A, Mondoni M, Mangoni AA, Zinellu A. The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients. Molecules [Internet]. 2020;25(23):5725. Disponible en: https://doi.org/10.3390/molecules25235725
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Copyright (c) 2023 Cinthya Verónica Acosta Santana, Minerva Casilda Donate Pino
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