Identificación de especies vegetales utilizadas en el tratamiento de la diabetes mellitus tipo 2, mecanismos de acción y modelos experimentales
Identification of species of plants used in the treatment of diabetes mellitus type 2, mechanisms of action and experimental models
DOI:
https://doi.org/10.33936/la_tecnica.v0i13.594Abstract
En el presente trabajo se realizó una revisión de la literatura sobre las investigaciones efectuadas con extractos de especies vegetales, en la diabetes mellitus tipo 2. El objetivo es analizar las investigaciones del uso ciertas especies vegetales en la diabetes, la insulina y las drogas naturales miméticas, los fitoconstituyentes que tienen potencial hipoglucémico y los modelos experimentales para evaluación de intolerancia a la glucosa y diabetes tipo 2. Se utilizó el método descriptivo inductivo, precisando las especies vegetales en las que se ha demostrado científicamente su actividad hipoglucémica y los mecanismos de acción que utilizan para producir el efecto antidiabético. Se explica la clasificación de los modelos experimentales utilizados para el estudio de la diabetes y una descripción de los modelos para la evaluación de los distintos tipos de diabetes, así como las ventajas y desventajas de los mismos. Se concluye que las especies vegetales influyen en la digestión y absorción de hidratos de carbono a través de la inhibición enzimática, y que algunos fitoconstituyentes demostraron actividad hipoglucémica con diferentes mecanismos de acción.
Palabras clave: fitoquímico, biomodelos, plantas medicinales,fitoconstituyentes, actividad hipoglucémica.
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References
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Mark, A.L; Shaffer, R.A; Correia, M.L.G; Morgan, D.A; Sigmund, C.D; & Haynes, W.G. (1999). Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. Journal of Hypertension. 17(12):1949–1953.
Maroo, J; Vasu, VT; & Gupt, S. (2003). Dose dependent hypoglycemic effect of aqueous extract of Enicostemma littorale Blume in alloxan in¬duced diabetic rats. Phytomedicine. 10(2-3): 196-9.
Martin, B; Ji S, Maudsley, S; & Mattson, M.P. (2010). Control” laboratory rodents are metabolically morbid: why it matters. Proceedings of the National Academy of Sciences of the United States of America. 107(14):6127–6133.
Martínez, N; Cayama, E; Goncalvez, L; Labrador, S;Espino, C; & Pérez; L. (2009). Efecto hipoglicemiante de la planta Bauhinia purpúrea L., en ratones euglicémicos.Comunidad y Salud. Jul-Dic; 7 (2): 44-50.
Martínez, N; Jiménez, R; Moreno, W; Lamont, L; Cayama, E; Espino, C; & Requena, D. (2011). Efecto hipoglucemiante de la planta Bixa orellana L., en conejos de la raza Nueva Zelanda y en medios de glucosa con células resuspendidas. Anuario de investigación en etnomedicina, medicinas complementarias y utilización de plantas medicinales.
Akar, F; Pektas, M.B; Tufan, C; Soylemez, S; Sepici, A; Ulus, A.T; Gokalp, B; Ozturk, K; & Surucu, H.S.(2011). Resveratrol shows vasoprotective effect reducing oxidative stress without affecting metabolic disturbances in insulin-dependent diabetes of rabbits. Cardiovascular
Drugs and Therapy. 25(2):119-131.
Association Diabetes American (ADA). (2004). Diagnosis and Classification of Diabetes Mellitus.Diabetes Care. 27: S5-S10.
Bigorgne, A.E; Bouchet-Delbos, L; Naveau, S; Dagher, I; Prévot, S; Durand-Gasselin, I; Couderc, J; Valet, P;Emilie, D; & Perlemuter, G. (2008). Obesity-induced lymphocyte hyperresponsiveness to chemokines: a new mechanism of fatty liver inflammation in obese mice.Gastroenterology. 134(5):1459–1469.
Bilfinger, T.V., Vosswinkel, J.A; Cadet, P; Rialas, C.M;Magazine, H.I; & Stefano, G.B. 2002. Direct assessment and diminished production of morphine stimulated NO by diabetic endothelium from saphenous vein. Acta Pharmacol Sin. 23(2): 97-102.
Bocarsly, M.E; Powell E.S; Avena, N.M; & Hoebel, B.G. (2010). High-fructose corn syrup causes characteristics of obesity in rats: increased body weight, body fat and triglyceride levels. Pharmacology Biochemistry and Behavior. 97(1):101–106.
Chun, M.R; Lee, YJ; Kim, K.H; Kim, Y.W; Park, S.Y; Lee, K.M; Kim, J.Y; & Park, Y.K. (2010). Differential effects of high-carbohydrate and high-fat diet composition on muscle insulin resistance in rats. Journal of Korean Medical Science. 25(7):1053–1059.
Ciangherotti, C; Orsini, G; Israel, A; & SalazarBookaman,M. (2012). Avances sobre la farmacología y la toxicología de la raíz de Ruellia tuberosa L. Abstract Book of XXI Italo LatinAmerican Congress of Ethnomedicine Edit by: Vincenzo Barbarulo, Luigi Russo & Luca Rastrelli © SILAE 2012 - www.silae.net ISBN: 9788890687341. p. 51-52.
Cooper, E.J; Hudson, A.L; Parker, C.A; & Morgan,N.G. (2003). Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans. Eur J Pharmacol. 482:189-96.
De la Torre, L; Muriel, P. & Balslev, H. (2006). Etnobotánica en los Andes del Ecuador. Botánica Económica de los Andes Centrales. 246-267.
Díaz, A; & Balibrea, J. (2007). Modelos animales de intolerancia a la glucosa y diabetes tipo 2. Nutr. Hosp. 22:2 (marzo-abril)
Gad, M.Z; El-Sawalhi, M.M; Ismail, M.F; & El-Tanbouly,ND. (2006). Biochemical study of the antidiabetic action of the Egyptian plants Fenugreek and Balanites. Mol Cell Biochem. 281(1&2): 173-83.
Ge, F; Zhou, S; Hu, C; Lobdell, H; & Berk, P.D. (2010). Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice. American Journal of Physiology. 299(4):G855–G866.
Hikino, H; Kobayashi, M; Suzuk, Y; & Konno C. (1989). Mechanisms of hypoglycemic activity of aconitan A, a glycan from Aconitum carmichaeli roots. J Ethnopharmacol. 25(3): 295-04.
Jamaludin, M; Saw, W; Muhd, H; Siti, B. & Satirah, Z. (2013). The protective effect of aqueous extracts of roselle (Hibiscus sabdariffa L. UKMR-2) against red blood cell membrane oxidative stress in rats with streptozotocininduced diabetes. Clinics. 68(10):1358-1363.
Ju, C; Yue, W; Yang, Z; Zhang, Q; Yang, X; Liu, Z; & Zhang; F. (2010). Antidiabetic effect and mechanism of chitooligosaccharides. Biological and Pharmaceutical Bulletin. 33(9):1511–1516.
Kawano, K; Hirashima, T; Mori, S; & Natori, T. (1994). OLETF (Otsuka Long-Evans Tokushima fatty) rat: a new NIDDM rat strain. Diabetes Research and Clinical Practice. 24(supplement):S317–S320.
Kumari, K; Mathew, B.C; & Augusti, K.T. (1995). Hypoglycemic and hypolipi-demic effects of S-methyl cysteine sulfoxide isolated from Allium cepa Linn. Indian J Biochem Biophys. 32: 49-54.
Lim, J.S; Mietus-Snyder, M; Valente, A; Schwar,zJ.M; & Lustig, R.H. (2010). The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome. Nature Reviews Gastroenterology and Hepatology.7(5):251–264.
Louhelainen, M; Vahtola, E; Forsten, H; Merasto,S; Kyto, V; Finckenberg, P; Leskinen, H; Kaheinen,P; Tikkanen, I; Levijoki, J; & Mervaala, E. (2009). Oral levosimendan prevents postinfarct heart failure and cardiac remodeling in diabetic Goto-Kakizaki rats.Journal of Hypertension. 27(10):2094–2107.
Mark, A.L; Shaffer, R.A; Correia, M.L.G; Morgan, D.A; Sigmund, C.D; & Haynes, W.G. (1999). Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. Journal of Hypertension. 17(12):1949–1953.
Maroo, J; Vasu, VT; & Gupt, S. (2003). Dose dependent hypoglycemic effect of aqueous extract of Enicostemma littorale Blume in alloxan in¬duced diabetic rats. Phytomedicine. 10(2-3): 196-9.
Martin, B; Ji S, Maudsley, S; & Mattson, M.P. (2010). Control” laboratory rodents are metabolically morbid: why it matters. Proceedings of the National Academy of Sciences of the United States of America. 107(14):6127–6133.
Martínez, N; Cayama, E; Goncalvez, L; Labrador, S;Espino, C; & Pérez; L. (2009). Efecto hipoglicemiante de la planta Bauhinia purpúrea L., en ratones euglicémicos.Comunidad y Salud. Jul-Dic; 7 (2): 44-50.
Martínez, N; Jiménez, R; Moreno, W; Lamont, L; Cayama, E; Espino, C; & Requena, D. (2011). Efecto hipoglucemiante de la planta Bixa orellana L., en conejos de la raza Nueva Zelanda y en medios de glucosa con células resuspendidas. Anuario de investigación en etnomedicina, medicinas complementarias y utilización de plantas medicinales.
Published
2014-12-01
How to Cite
Dueñas Rivadeneira, A. A. (2014). Identificación de especies vegetales utilizadas en el tratamiento de la diabetes mellitus tipo 2, mecanismos de acción y modelos experimentales: Identification of species of plants used in the treatment of diabetes mellitus type 2, mechanisms of action and experimental models. La Técnica. Revista De Las Agrociencias. ISSN 2477-8982, (13), 64–73. https://doi.org/10.33936/la_tecnica.v0i13.594
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