Degradación fotoelectroquímica de mesilato de imatinib utilizando un fotoánodo BDD/TiO2: Una comunicación corta.: Degradación fotoelectroquímica de mesilato de imatinib

Patricio Espinoza-Montero; Steven Mateo Vélez Zambrano; G. Xavier Castillo-Cabrera; Gustavo Altamirano-Briones

doi:10.33936/revbasdelaciencia.v10i3.7677

Authors

Patricio Espinoza-Montero Pontificia Universidad Católica del Ecuador
Steven Mateo Vélez Zambrano Pontificia Universidad Católica de Ecuador, Quito, Ecuador. Universidad Técnica de Manabí, Portoviejo, Ecuador https://orcid.org/0009-0003-8314-2417
G. Xavier Castillo-Cabrera Pontificia Universidad Católica de Ecuador, Quito, Ecuador.
Gustavo Altamirano-Briones Universidad Técnica de Manabí, Portoviejo, Ecuador. Programa de Doctorado en Ciencia y Tecnología Industrial y Ambiental, Universidad Huelva, Huelva, España. https://orcid.org/0000-0002-9360-9610

DOI:

https://doi.org/10.33936/revbasdelaciencia.v10i3.7677

Keywords:

Imatinib mesylate (IMB), Photoelectrocatalysis (PEC), Photoanode, Electrophoretic deposition, Boron Doped Diamond (BDD), Titanium Dioxide (TiO2).

Abstract

Imatinib (IMB) is an enzymatic inhibitor that prevents the proliferation of cancer cells. It is used to treat certain types of cancer, such as leukemia, and is also effective in the treatment of specific gastrointestinal stromal tumors and dermatofibrosarcoma protuberans. After administration, it is excreted through urine and feces. The concentration of IMB in the environment is increasing rapidly, leading to serious environmental and human health concerns. This study employs a boron-doped diamond photoanode modified with titanium dioxide (BDD/TiO₂) for the degradation of IMB via photoelectrocatalysis. The research was divided into three stages: i) modification of the BDD electrode through electrophoretic deposition of synthetic TiO₂ nanoparticles; ii) electrochemical characterization of the BDD/TiO₂ photoanode; iii) degradation of imatinib (24 mg L⁻¹) through electrochemical oxidation using BDD and photoelectrocatalysis with BDD/TiO₂ at various current densities over 90 minutes. Degradation and mineralization were monitored using UV spectroscopy and chemical oxygen demand (COD) analysis. The highest photoelectrocatalytic degradation rate of IMB reached 84.09% when applying a current density of 8.26 mA cm⁻².

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Degradación fotoelectroquímica de mesilato de imatinib utilizando un fotoánodo BDD/TiO2: Una comunicación corta.