Degradación fotoelectroquímica de mesilato de imatinib utilizando un fotoánodo BDD/TiO2: Una comunicación corta.: Degradación fotoelectroquímica de mesilato de imatinib

Patricio Espinoza-Montero; Steven Mateo Vélez Zambrano; G. Xavier Castillo-Cabrera; Gustavo Altamirano-Briones

doi:10.33936/revbasdelaciencia.v10i3.7677

Autores

Patricio Espinoza-Montero Pontificia Universidad Católica del Ecuador
Steven Mateo Vélez Zambrano Pontificia Universidad Católica de Ecuador, Quito, Ecuador. Universidad Técnica de Manabí, Portoviejo, Ecuador https://orcid.org/0009-0003-8314-2417
G. Xavier Castillo-Cabrera Pontificia Universidad Católica de Ecuador, Quito, Ecuador.
Gustavo Altamirano-Briones Universidad Técnica de Manabí, Portoviejo, Ecuador. Programa de Doctorado en Ciencia y Tecnología Industrial y Ambiental, Universidad Huelva, Huelva, España. https://orcid.org/0000-0002-9360-9610

DOI:

https://doi.org/10.33936/revbasdelaciencia.v10i3.7677

Palavras-chave:

Mesilato de imatinib (IMB), Fotoelectrocatálisis (FEC), Fotoánodo, Depósito electroforético, Diamante Dopado con Boro (BDD), Dióxido de Titanio (TiO2).

Resumo

O imatinibe (IMB) é um inibidor enzimático que impede a proliferação de células cancerígenas. É utilizado no tratamento de certos tipos de câncer, como a leucemia. Também é eficaz no tratamento de determinados tipos de tumores do estroma gastrointestinal (GIST) e do dermatofibrossarcoma protuberante. Após sua administração, é eliminado por meio da urina e das fezes. A concentração de IMB no ambiente está aumentando rapidamente, causando sérios problemas ambientais e riscos à saúde humana. Este estudo utiliza um fotoânodo de diamante dopado com boro, modificado com dióxido de titânio (BDD/TiO₂), para a degradação do IMB por meio da fotoeletrocatálise. A pesquisa foi dividida em três etapas: i) modificação do eletrodo BDD por deposição eletroforética de nanopartículas sintéticas de TiO₂; ii) caracterização eletroquímica do fotoânodo BDD/TiO₂; iii) degradação do imatinibe (24 mg L⁻¹) por oxidação eletroquímica com BDD e fotoeletrocatálise com BDD/TiO₂ sob diferentes densidades de corrente durante 90 minutos. A degradação e a mineralização foram monitoradas por espectroscopia UV e pela análise de demanda química de oxigênio (DQO). A taxa máxima de degradação fotoeletrocatalítica do IMB foi de 84,09%, aplicando uma densidade de corrente de 8,26 mA cm⁻².

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Degradación fotoelectroquímica de mesilato de imatinib utilizando un fotoánodo BDD/TiO2: Una comunicación corta.